Chemically Sustainable and Green One-Pot Multicomponent Synthesis of Highly Functionalized Polycyclic N-Fused-Pyrrolidine Heterocycles
acenaphthenequinone, cascade reaction, green synthesis, heterocycles, N-fused-pyrrolidine
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim An eco-friendly, highly-eﬃcient, atom-economical three-component cascade reaction of acenaphthenequinone (8), β-nitroolefins (9) and α-amino acid (10) in MeOH/H2O is developed for the synthesis of novel functionalized polycyclic N-fused-pyrrolidine derivatives (11). All products are obtained by filtration in the absence of column chromatography and recrystallization. Due to its operational simplicity, this green and chemically sustainable reaction can be easily applied toward the design and synthesis of target molecules for the discovery of novel biologically active compounds.
Yan, Li Jun; Wang, Jun Liang; Xu, Dan; Burgess, Kevin S.; Zhu, Ai Fei; Rao, Yan Ying; Chen, Xue Bing; and Wang, Yong Chao, "Chemically Sustainable and Green One-Pot Multicomponent Synthesis of Highly Functionalized Polycyclic N-Fused-Pyrrolidine Heterocycles" (2018). Faculty Bibliography. 2908.