Title

Chemically Sustainable and Green One-Pot Multicomponent Synthesis of Highly Functionalized Polycyclic N-Fused-Pyrrolidine Heterocycles

Document Type

Article

Publication Date

1-1-2018

Publication Title

ChemistrySelect

Volume

3

First Page

662

Last Page

665

Keywords

acenaphthenequinone, cascade reaction, green synthesis, heterocycles, N-fused-pyrrolidine

Abstract

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim An eco-friendly, highly-efficient, atom-economical three-component cascade reaction of acenaphthenequinone (8), β-nitroolefins (9) and α-amino acid (10) in MeOH/H2O is developed for the synthesis of novel functionalized polycyclic N-fused-pyrrolidine derivatives (11). All products are obtained by filtration in the absence of column chromatography and recrystallization. Due to its operational simplicity, this green and chemically sustainable reaction can be easily applied toward the design and synthesis of target molecules for the discovery of novel biologically active compounds.

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