Author

Jared J. Bies

Date of Award

2018

Type

Thesis

Major

Art

Degree Type

Bachelor of Arts

Department

Chemistry

First Advisor

Jonathan Meyers

Second Advisor

Kerri Taylor

Third Advisor

Cindy Ticknor

Abstract

Novel triazolium, imidazolium, and benzimidazolium salts are known to possess anti-cancer properties and have potential as cancer therapeutics. This thesis describes the aqueous solubility and the differential activity of N,AT-bis-substituted-l,2,4-triazolium bromide salts and N/N'-bis(naphthylmethyl)imidazolium bromide salts against MDA-MB-468 breast cancer cells and PC-3 prostate carcinomas. Using a microscale technique, the partition coefficient (log P) of each salt was determined. The log P value was explored to determine the bioavailability of each derivative.

Included in

Chemistry Commons

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