Date of Award
Bachelor of Arts
Novel triazolium, imidazolium, and benzimidazolium salts are known to possess anti-cancer properties and have potential as cancer therapeutics. This thesis describes the aqueous solubility and the differential activity of N,AT-bis-substituted-l,2,4-triazolium bromide salts and N/N'-bis(naphthylmethyl)imidazolium bromide salts against MDA-MB-468 breast cancer cells and PC-3 prostate carcinomas. Using a microscale technique, the partition coefficient (log P) of each salt was determined. The log P value was explored to determine the bioavailability of each derivative.
Bies, Jared J., "Correlation of Aqueous Solubility and Anti-Cancer Activity of Novel Triazolium and Imidazolium Salts" (2018). Theses and Dissertations. 338.