Correlation of Aqueous Solubility and Anti-Cancer Activity of Novel Triazolium and Imidazolium Salts
Date of Award
2018
Type
Thesis
Major
Chemistry
Degree Type
Bachelor of Arts
Department
Chemistry
First Advisor
Jonathan Meyers
Second Advisor
Kerri Taylor
Third Advisor
Cindy Ticknor
Abstract
Novel triazolium, imidazolium, and benzimidazolium salts are known to possess anti-cancer properties and have potential as cancer therapeutics. This thesis describes the aqueous solubility and the differential activity of N,AT-bis-substituted-l,2,4-triazolium bromide salts and N/N'-bis(naphthylmethyl)imidazolium bromide salts against MDA-MB-468 breast cancer cells and PC-3 prostate carcinomas. Using a microscale technique, the partition coefficient (log P) of each salt was determined. The log P value was explored to determine the bioavailability of each derivative.
Recommended Citation
Bies, Jared J., "Correlation of Aqueous Solubility and Anti-Cancer Activity of Novel Triazolium and Imidazolium Salts" (2018). Theses and Dissertations. 338.
https://csuepress.columbusstate.edu/theses_dissertations/338
